Which statement about zygosity testing in prenatal NIPT is true?

Which statement about zygosity testing in prenatal NIPT is true?

• A. Panorama is the only NIPT to determine zygosity prenatally
• B. Zygosity cannot be determined prenatally by any NIPT
• C. Zygosity determination is only possible after birth
• D. No NIPT can determine zygosity

Answer: (A)

Zygosity determination in a twin pregnancy with NIPT hinges on analyzing the genetic material from the two fetuses present in maternal blood. Panorama uses targeted SNP analysis and comparative genotyping across both fetuses to decide whether the twins share identical genetic material (monozygotic) or have different genetic makeup (dizygotic). This prenatal zygosity call is a distinctive feature of Panorama, because many other NIPT platforms are geared toward single-fetus aneuploidy screening and do not provide a reliable prenatal zygosity assessment. In this context, Panorama is the NIPT that can determine zygosity prenatally.

Zygosity determination in a twin pregnancy with NIPT hinges on analyzing the genetic material from the two fetuses present in maternal blood. Panorama uses targeted SNP analysis and comparative genotyping across both fetuses to decide whether the twins share identical genetic material (monozygotic) or have different genetic makeup (dizygotic). This prenatal zygosity call is a distinctive feature of Panorama, because many other NIPT platforms are geared toward single-fetus aneuploidy screening and do not provide a reliable prenatal zygosity assessment. In this context, Panorama is the NIPT that can determine zygosity prenatally.